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Specifications
- Target protein:IL-2
- Description:Swine IL-2 ELISA KIT
- Size:1 kit
- Cat. No.:102993-492
- Supplier no.:IL251-K01
Specifications
About this item
Swine IL-2 ELISA detects Swine IL-2 concentrations in cell culture supernates, serum, and plasma.
- Dynamic Range: 3.9 - 125 pg/ml
- Sensitivity: 2 pg/ml
- Incubation: 3.0 hours
Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or Antigens-activated T lymphocytes (1, 2). Human IL-2 (also known as T-cell growth factor) is produced by T-cells in response to Antigensic or mitogenic stimulation. IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells promoting proliferation and maturation.
IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendocytes. IL-2 is involved in treatment of cancers such as melanoma and renal cell cancer. It plays a key role in promoting the clonal expansion of Antigens-specific T cells. In addition, IL-2 has also been shown to mediate multiple immune responses on a variety of cell types. At the amino acid sequence level, there is approximately 72% similarity between mature porcine and human IL-2. The biological effects of IL-2 are mediated by specific cell surface receptor complexes. The functional high-affinity receptor for IL-2 is composed of three distinct polypeptide chains (3, 4). IL-2 stimulates the proliferation of thymocytes; stimulates the proliferation and differentiation of activated B cells; promotes the growth, differentiation and cytocidal activity of monocytes; induces the growth of natural killer cells and stimulates cytokine production by these cells as well as the cytolytic activity of these cells; enhances the production of lymphocyte-activated killer (LAK) cells; and induces the proliferation and differentiation of oligodendrocytes (1, 2).