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- Primary antibody reactivity:Mouse
- Target protein:IL-25 (IL-17E)
- Description:Mouse IL-25 (IL-17E) ELISA KIT
- Size:1 kit
- Cat. No.:102994-732
- Supplier no.:L2511-K01
Mouse IL-25 IL-17E EIA detects mouse IL-25, IL-17E concentrations in cell culture supernates, serum.
- Dynamic Range: 31.25 - 1000 pg/ml
- Sensitivity: 15 pg/ml
- Incubation: 3.5 hours
IL-25 (also known as IL-17E) is a member of the IL-17 family of proinflammatory cytokines, which includes IL-17A, IL-17B, IL-17C, IL-17F and IL-17A/F. IL-17E is found at low levels in various peripheral tissues. It is a proinflammatory cytokine that promotes airway eosinophilia in mice. IL-17E plays a role in Th2 type inflammatory diseases, such as asthma and atopic dermatitis. IL-25 induces elevated gene expression of IL-4, IL-5 and IL-13 in multiple tissues and results in T helper 2 (TH2)-type immune responses (increased serum IgE levels) and pathologic changes in the lungs and digestive tract with eosinophilic infiltrates, increased mucus production, epithelial cell hyperplasia and overall amplified allergic inflammation. IL-25 shares the receptor IL-17RB with IL-17B, although it binds with much higher affinity than IL-17B.