Zeta Plus BC Series Filter Capsules with SP Series Media for biological, small molecule pharmaceutical, and food and beverage manufacturing applications where an optimized balance of throughput and particle removal efficiency is critical. These capsules, having the same media as production products, are ideal for assessing filtration media grades using low challenge fluid volumes.

• Zeta Plus SP Series filter media is offered in the largest selection of grades in the 3M depth filter portfolio with a range of porosity and tightness suitable for diverse applications from cell culture harvest to fine clarification
• Single layer media configurations are available in capsule and cartridge formats for high surface loading filtration applications
• BC25 Laboratory capsules contain same media as in production scale systems and are ideal for selecting the optimum media grade using low challenge fluid volume
• Full range of scalable single-use capsules and cartridges enables predictable performance from the laboratory to commercial production

Zeta Plus SP Series filter media is a mixture of high surface area inorganic particles, cellulose and a positively charged crosslinking polymer.

The combination of filtration efficiency and throughput results from the balance between media porosity, depth, and the relatively low level anion exchange capacity: removing some negatively charged soluble contaminants and sub-micron particles via anion exchange and larger particles by mechanical sieving. Single layer formats are offered in our highest filter surface area, making them the preferred choice over double layer formats for hard particle removal and predominantly surface loading filtration applications. The Zeta Plus™ BC Series Filter Capsule with SP Series media is ideal for optimizing the filtration performance for each drug process by effectively screening the breadth of available media options. A scalable range of single-use capsules and cartridges enables predictable performance at every stage of drug development from early stage discovery to commercial production.

Pharmaceutical Grade Product.

The Zeta Plus™ BC Series Filter Capsules with SP Series Media are designed for use in the manufacture of biopharmaceutical, vaccine, blood fractionation, small molecule API drug substances, and food and beverages. The effluent characteristics of the Zeta Plus SP Series Filter media, capsules and cartridges have been tested following a number of protocols contained in the United States Pharmacopeia (USP) compendia.

Filtration Performance
Zeta Plus SP Series filter media is a mixture of high surface area inorganic particles, high surface area cellulose and a crosslinking polymer resin. The polymer resin has a positive charge as a result of a unique balance of secondary, tertiary and quaternary amines resulting in a relatively low anion exchange capacity. As such, Zeta Plus™ BC Series Filter Capsules with SP Series Media are a good choice in applications where the target product is negatively charged and product recovery may be of concern. By controlling the choice of raw materials and the formulation, a very large selection of filtration grades are produced, each with a unique balance of fine particle removal and throughput capacity.
Scalable Single-use Capsules
A full range of scalable filter product configurations enables predictable performance at every stage of drug development from early stage discovery to commercial production. Specifically, the 3M™ Encapsulated System enables a completely single‐use solution to process from 0.5 L to 2500+ L of liquid. The BC25 laboratory capsule with 25 cm²; filter media is ideal for media grade screening using small liquid volumes. The scale‐up capsules with 170; 340 and 1020 cm²; media are designed for scale‐up studies and low volume production. Production capsules having 0.23 m² and 2.5 m² single layer media complete the single-use capsule line.