Zeta Plus™ BC Series Filter Capsule with DELP08 Series Media utilizes precipitated silica adsorbents that help reduce lipids, surfactants and, potentially, other biological contaminants from human blood plasma, serum-based products, recombinant proteins and other biological fluids. These two media types provide a range of lipid reduction capacity.

• May help reduce undesirable lipids, lipoprotein haze, and microbial and particulate contaminants
• Full range of cartridge and capsule filter sizes to enable laboratory to full-scale production operation
• All product components comply with USP Class VI Biological Reactivity Tests, in vivo

Problem:

During protein purification processes, lipid contamination can cause an assortment of processing problems. Lipids can foul and plug expensive chromatography columns and membrane filters. Lipid contamination can also cause solution instability of intermediate and final protein products leading haze.

Solution:

Our Zeta Plus™ BC Series filter capsules with DELP08 media may be an option to replace bulk precipitated silica operations, which are labor-intensive and require multiple operations to implement. Zeta Plus DEL08 series media can be used to help remove the following lipid classes: mono-, di-, and triglycerides, fatty acids, cholesterol, phospholipids, and lipoproteins. Reduction of lipid contaminants from protein solutions may lead to improved processing economies (e.g., extended column and membrane life), improved product purity, and increased final protein product stability. We manufacture Zeta Plus BC Series Filter Capsules using fluid contact components are compliant to USP <88> Class VI Biological Reactivity Tests.