L(+)-Aspartic acid, EMPROVE® ESSENTIAL BP, Ph. Eur., USP, SAFC®

: (S)-(+)-Aminosuccinic acid (S)-Aminobutanedioic acid (S)-Aminosuccinic acid H-Asp-OH L-Asparaginic acid L(+)-Aspartic acid, (S)-(+)-Aspartic acid, L(+)-2-Amino-1,4-butanedioic acid, (S)-(+)-2-Amino-1,4-butanedioic acid, L-Aspartic acid, H-Asp-OH, L-α-Aminosuccinic acid, L-αlpha-Aminosuccinic acid, (S)-2-Aminosuccinic acid, Asp, D

:56-84-8

:C₄H₇NO₄

:MFCD00002616

:311

:133.1 g/mol

:251 (dec.)

:13,00845

:Ambient

:200-291-6

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Environmentally Preferable:

Assay (alkalimetric, calculated on dried substance):
98.5 - 101.5 %
Identity (IR-spectrum):
passes test
Identity (enantiomeric purity):
passes test
Appearance:
white to almost white, crystalline powder or colorless crystals
Appearance of solution (50 g/l; hydrochloric acid 1 mol/l):
clear and not more intense in color than reference solution BY₆
Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 6 mol/l, calc. on dried substance):
+24.0 to +26.0
Chloride (Cl):
≤ 200 ppm
Sulfate (SO₄):
≤ 300 ppm
Fe (Iron):
≤ 10 ppm
Enantiomeric purity (HPLC) (D-aspartic acid):
≤ 0.3 %
Dicarboxylic acids (HPLC) (malic acid):
≤ 0.2 %
Dicarboxylic acids (HPLC) (fumaric acid):
≤ 0.10 %
Dicarboxylic acids (HPLC) (maleic acid):
≤ 0.10 %
Dicarboxylic acids (HPLC) (any unspecified impurity):
≤ 0.10 %
Dicarboxylic acids (HPLC) (total unspecified impurities):
≤ 0.3 %
Related compounds (HPLC) (maleic acid):
≤ 0.05 %
Related compounds (HPLC) (malic acid):
≤ 0.20 %
Related compounds (HPLC) (fumaric acid):
≤ 0.10 %
Related compounds (HPLC) (any unspecified impurity):
≤ 0.05 %
Related compounds (HPLC) (total unspecified impurities):
≤ 0.10 %
Ninhydrin-positive substances (LC)(impurity C (glutamic acid)):
≤ 0.2 %
Ninhydrin-positive substances (LC)(impurity D (alanine)):
≤ 0.2 %
Ninhydrin-positive substances (LC)(impurity G (asparagine)):
≤ 0.2 %
Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity):
≤ 0.10 %
Ninhydrin-positive substances (LC) (total impurities):
≤ 1.0 %
Ninhydrin-positive substances (LC) (ammonium (570 nm)):
≤ 0.02 %
Residual solvents (ICH Q3C):
excluded by manufacturing process
Sulfated ash (600 °C):
≤ 0.1 %
Loss on drying (105 °C; 3 h):
≤ 0.5 %