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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:CHO cells
- Species:Mouse
- Size:100 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<0.06EU/µg
- Gene ID:NP_032824.1
- Protein Synonyms:PD-1|Programmed Cell Death Protein 1
- Protein/Peptide Name:CD279
- Purity:98%
- Endotoxin Level:Low
- Formulation:Lyophilized from 0.2µm-filtered solution in PBS.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102981-538
- Supplier no.:MF110PD1C100
Specifications
About this item
CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.