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- Conjugation:Unconjugated
- Protein Function:Interleukins
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Mouse
- Size:10 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<0.01EU/µg
- Biological Activity:Induces secretion of IL-6 in BMDCs.
- Gene ID:Q8R460
- Amino Acid Number:13 to 164
- Protein Synonyms:Interleukin-36gamma|Interleukin-1 Family Member 9|IL-1F9
- Protein/Peptide Name:IL-36gamma
- Purity:95%
- Molecular Weight:~17kDa
- Endotoxin Level:Low
- Concentration:0.1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102978-744
- Supplier no.:AG40B0105C010
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.