Human Recombinant Progranulin (from HEK293 Cells)

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

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Conjugation:
Unconjugated
Protein/Peptide Type:
Recombinant
Source:
HEK293 cells
Species:
Human
Storage Conditions:
–20 °C
Endotoxin Content:
<5EU/mg
Biological Activity:
Activates ERK phosphorylation in THP-1 and MCF10A cells and induces cell migration of THP-1 monocytic leukemia cells.
Gene ID:
P28799
Protein Synonyms:
PC Cell-derived Growth Factor|Proepithelin|PEPI
Protein/Peptide Name:
Progranulin
Purity:
98%
Molecular Weight:
~76kDa (SDS-PAGE)
Endotoxin Level:
Low
Concentration:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
Formulation:
Lyophilized. Contains PBS.
Shipping Temperature:
-20 °C, Blue Ice