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Specifications
- Antibody Type:Primary
- Antigen Symbol:LTBETAR
- Clonality:Monoclonal
- Clone:ANCLTR2/9E2
- ELISA:Yes
- Flow Cytometry:Yes
- Isotype:IgG1 kappa
- Reactivity:Human
- Size:120 tests
- Form:liquid
- Antigen Synonyms:Tumor Necrosis Factor Receptor Superfamily Member 3|Lymphotoxin-beta Receptor|Tumor Necrosis Factor Receptor 2 Related Protein|TNFRSF3|Tumor Necrosis Factor C Receptor
- Storage Temperature:+4°C
- Shipping Temperature:-20° C
- Immunogen:Recombinant Human LT.
- Cat. No.:102512-726
- Supplier no.:ANC267040
Specifications
About this item
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Type: Primary
Antigen: LTBETAR
Clonality: Monoclonal
Clone: ANCLTR2/9E2
Conjugation: FITC
Epitope:
Host:
Isotype: Mouse IgG1kappa
Reactivity: Human