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Specifications
- Antibody Type:Primary
- Antigen Symbol:PARP-1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:
- Reactivity:Monkey,Human,Mouse
- Western Blot:Yes
- Size:100 µl
- Environmentally Preferable:
- Form:liquid
- Gene ID:P09874
- Antigen Synonyms:ADP-ribosyltransferase Diphtheria Toxin-like 1|NAD(+) ADP-ribosyltransferase 1|Poly(ADP-ribose) Polymerase 1
- Storage Temperature:–20 °C
- Shipping Temperature:-20° C
- Immunogen:Recombinant human PARP-1 [ARTD1] (aa 215-525).
- Cat. No.:102979-952
- Supplier no.:AG25T0002R100
Specifications
About this item
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Type: Primary
Antigen: PARP-1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Monkey, Mouse