In vivo SilenceMag is a rapid, simple and highly efficient method dedicated to transfect small RNA (siRNA, miRNA) into target cells/tissue in vivo.

• Increased silencing efficiency
• Targeted process (magnetically-driven)
• Reduction of the systemic dissemination of siRNA/miRNA during injection
• Reduction of the siRNA/miRNA doses
• Work under non permissive conditions (hypothermia, physiological flow conditions)
• Penetration of the siRNA/miRNA into tissues
• Minimized toxicity

It combines magnetic nanoparticles and small RNA that will be retained after injection at the magnetically targeted site. This targeted delivery method minimizes systemic distribution, increases gene targeted inactivation and reduces toxicity.