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Specifications
- Antibody Type:Primary
- Antigen Name:CD8alpha
- Antigen Symbol:CD8alpha
- Clonality:Monoclonal
- Clone:53-6.7
- Conjugation:APC (Allophycocyanin)/Cy7®
- Flow Cytometry:Yes
- Host:Rat
- Isotype:IgG2a
- Reactivity:Mouse
- Size:0.1 mg
- Environmentally Preferable:
- Form:Liquid
- Gene ID:12525
- Antigen Synonyms:T8|Ly-2|Lyt-2|Ly-35|Ly-B
- Storage Buffer:Supplied in PBS/NaN3 and a stabilizing agent
- Storage Temperature:2-8°C
- Concentration:0.1 mg/mL
- Shipping Temperature:Ambient Temperature
- Immunogen:Spleen cells or thymocyte membranes
- Cat. No.:101190-304
- Supplier no.:1550-19
Specifications
About this item
In the mouse, CD8 exists in two forms – (i) a CD8 heterodimer composed of an α chain (CD8α) and a β chain (CD8β); and (ii) a homodimer of two α chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8α without CD8β. It has been suggested that CD8+β- T cells mature extrathymically, while development of the CD8α+β+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8α+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.
Type: Primary
Antigen: CD8alpha
Clonality: Monoclonal
Clone: 53-6.7
Conjugation: APC (Allophycocyanin)/Cy7®
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse