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Specifications
- Antibody Type:Primary
- Antigen Name:H-2Db
- Antigen Symbol:H-2Db
- Clonality:Monoclonal
- Clone:28-14-8
- Conjugation:RPE (R-Phycoerythrin)
- Flow Cytometry:Yes
- Host:Mouse
- Isotype:IgG2a
- Reactivity:Mouse
- Size:0.1 mg
- Form:Liquid
- Gene ID:14964
- Antigen Synonyms:MHC Class I
- Storage Buffer:Supplied in PBS/NaN3 and a stabilizing agent
- Storage Temperature:2-8°C
- Concentration:0.1 mg/mL
- Shipping Temperature:Ambient Temperature
- Immunogen:C3H.SW mouse splenocytes
- Cat. No.:100244-094
- Supplier no.:1910-09
Specifications
About this item
The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic α chains noncovalently associated with the invariant β2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. The monoclonal antibody 28-14-8 binds to the α3 domain of H-2Db in the presence or absence of β2 microglobulin. It cross reacts with the α3 domain of H-2Ld, but not Kd or Dd, and with H-2Dq and/or Lq. The antibody has been shown to block H-2Ld-specific and H-2Ld-restricted antigen-specific lysis of target cells by cytotoxic T lymphocytes but it does not block recognition of H-2Ld-positive target cells by Ly-6G2-positive NK cells.
Type: Primary
Antigen: H-2Db
Clonality: Monoclonal
Clone: 28-14-8
Conjugation: RPE (R-Phycoerythrin)
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Mouse