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Specifications
- Antibody Type:Primary
- Antigen Name:CD22
- Antigen Symbol:CD22
- Clonality:Monoclonal
- Clone:2D6
- Conjugation:Spectral Red® RPE (R-Phycoerythrin)/Cy5®
- Flow Cytometry:Yes
- Host:Rat
- Isotype:IgG1
- Reactivity:Mouse
- Size:0.1 mg
- Environmentally Preferable:
- Form:Liquid
- Gene ID:12483
- Antigen Synonyms:BL-CAM|Lyb-8|Leu-14
- Storage Buffer:Supplied in PBS/NaN3 and a stabilizing agent
- Storage Temperature:2-8°C
- Concentration:0.1 mg/mL
- Shipping Temperature:Ambient Temperature
- Immunogen:Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
- Cat. No.:100243-306
- Supplier no.:1580-13
Specifications
About this item
CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.
Type: Primary
Antigen: CD22
Clonality: Monoclonal
Clone: 2D6
Conjugation: Spectral Red® RPE (R-Phycoerythrin)/Cy5®
Epitope:
Host: Rat
Isotype: IgG1
Reactivity: Mouse