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- Antibody Type:Primary
- Antigen Name:Ly-49C/F/H/I
- Antigen Symbol:Ly-49C/F/H/I
- Clonality:Monoclonal
- Clone:14B11
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Flow Cytometry:Yes
- Host:Hamster
- Isotype:IgG
- Reactivity:Mouse
- Size:0.5 mg
- Form:Liquid
- Gene ID:16634/16637/16639/16640
- Antigen Synonyms:Ly-49
- Storage Buffer:Supplied in PBS/NaN3
- Storage Temperature:2-8°C
- Concentration:0.5 mg/mL
- Shipping Temperature:Ambient Temperature
- Immunogen:IL-2 activated natural killed (A-LAK) cells from C57BL/6 mice
- Cat. No.:100243-826
- Supplier no.:1801-02
The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H, and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains ~90% of NK1.1+CD3- splenocytes and ~6% of CD8+ spleen cells from C57BL/6 mice. The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
Type: Primary
Antigen: Ly-49C/F/H/I
Clonality: Monoclonal
Clone: 14B11
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Hamster
Isotype: IgG
Reactivity: Mouse