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Specifications
- Target protein:IL-2
- Description:Interleukin-2 (IL-2) Rat ELISA
- Size:1 kit
- Regulatory Status:RUO
- Cat. No.:102552-360
- Supplier no.:RAF054R
Specifications
About this item
Interleukin-2 (IL-2) plays a central role in the activation and proliferation of lymphocytes that have been primed by antigens.
- Calibration Range: 62.5-2000 pg/mL
- Limit of Detection: 11 pg/mL
- Body fluids, Cell culture supernatant, Serum: 50 uL/well
Interleukin-2 (IL-2) plays a central role in the activation and proliferation of lymphocytes that have been primed by antigens. IL-2 plays a pivotal role in for the expansion of most T-cells, natural killer cells and B-cells during certain phases of their response. IL-2 gene expression is regulated at the transcriptional level by several activation pathways. Antigen-specific proliferation of helper and cytotoxic T-lymphocytes following stimulation is critically dependent on IL-2 expression, secretion, and binding to receptors for IL-2 induced in an autocrine fashion on the surface of T-cells. Apart from its most important role to mediate antigen-specific T-lymphocyte proliferation, IL-2 modulates the expression of IFN-g and major histocompatibility antigens, stimulates proliferation and differentiation of activated B-cells, augments natural killer cell activity and inhibits granulocyte-macrophage colony formation. Alterations in the ability of T-cells to synthesize IL-2 have been observed in physiologic and pathologic states.