Backpressure regulators can improve detector performance by preventing bubble formation in the detector flow cell.

They also are useful in post-column reaction lines and between detectors and fraction collectors in preparatory work. Regulators are superior to more specific alternative solutions, like small-bore tubing, in which pressure varies with flow rate. Our end-of-line and flow-through backpressure regulators are adjustable to ensure constant backpressure over a wide range of mobile phase viscosities and flow rates. The end-of-line model is available with 1/4-28 plastic flange-type fittings or high-pressure 1/16" compression fittings; this design adjusts from 15 to 60 psi (103 to 414 kPa). The flow-through design has 1/16" compression fittings and is adjustable from 7 to 75 psi (48 to 517 kPa).