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Mouse Recombinant GDF8
Mouse Recombinant GDF8
Catalog # 75789-910
Supplier:  Avantor
CAS Number:  
Mouse Recombinant GDF8
Catalog # 75789-910
Supplier:  Avantor
CAS Number:  

Specifications

  • Protein/Peptide Type:
    Recombinant
  • Species:
    Mouse
  • Size:
    0.05 mg
  • Tag sequence:
    C-6 His tag
  • Storage Conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Endotoxin Content:
    <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • Protein Synonyms:
    GDF-8|Mstn|Growth/differentiation factor 8|Myostatin|Gdf8
  • Protein/Peptide Name:
    GDF8
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular Weight:
    28.4 kD
  • Sequence:
    Asn25-Ser265
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested Applications:
    Bioassay
  • Cat. No.:
    75789-910
  • Supplier no.:
    91-625

Specifications

About this item

Mouse Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues. Experiments in mice have improved that GDF-8 is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking Myostatin encoding gene show decreased body fat and a generalized increase in bone density and strength.

  • Fusion-Tag: C-6 His tag

This recombinant protein can be used for biological assays. For research use only.