Order Entry
United States
ContactUsLinkComponent
Human Recombinant LR3-IGF-1 (from E. coli)
Human Recombinant LR3-IGF-1 (from E. coli)
  75788-758
 :  Prosci
 :  
Human Recombinant LR3-IGF-1 (from E. coli)
  75788-758
 :  Prosci
 :  91-017
 :  
Restricted Products: To process your orders without delay, please provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:

  • • State issued document with your organization's Federal Tax ID Number
  • • State issued document with your organization's Resale Tax ID Number
  • • City or County issued Business License
  • • State Department of Health Services License
  • • Any other ID issued by the State that includes the business name & address

* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. Avantor will not lift restrictions for residential shipping addresses.

 

  • Protein/Peptide Type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Size:
    0.05 mg
  • Environmentally Preferable:
  • Storage Conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Endotoxin Content:
    <0.05 ng/ug (0.5 IEU/ug) as determined by LAL test.
  • Biological Activity:
    ED50 is greater than 200 ng/ml as determined by an IGF binding protein assay.
  • Protein Synonyms:
    IBP1|IGF1|Mechano Growth Factor|IGF-I|Insulin-like Growth Factor I|MGF|Somatomedin-C
  • Protein/Peptide Name:
    LR3-IGF-1
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular Weight:
    9.1 kD
  • Sequence:
    Gly49-Ala118
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of 300mM HAc-NaAc, pH 6.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in 500mM Acetic Acid. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested Applications:
    Bioassay
  • Cat. No.:
    75788-758
  • Supplier no.:
    91-017

 

 

Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.

This recombinant protein can be used for biological assays. For research use only.