p57 Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57 Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms. Positive Control: LS174T cells, Colon CA or placenta; Cellular Localization: Nuclear; Recommended for: Immunohistochemistry (Formalin/paraffin), Western Blotting (Not suitable), Immunoprecipitation (Native verified)

Type: Primary
Antigen: P57KIP2
Clonality: Monoclonal
Clone: 57P06
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human, Mouse