Mouse Recombinant Caspase 8 (from E. coli)

Supplier: Avantor

Certificates

Supplier: Avantor

About this item

A cysteine-aspartic acid protease involved in apoptosis

Caspase-8 (also know as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases

The recombinant active mouse caspase-8 was expressed in E. coli. The active caspase-8 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-IETD-pNA (Cat. #1063-200) or Ac-IETD-AFC (1062-200).

Similar to other caspases, caspase-8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of caspase-8 consists of large and small subunits which associate to form the active enzyme. Active caspase-8 has been shown to activate caspase-3 leading to degradation of a variety of cellular target proteins during apoptosis.

Restricted Products: To process your orders without delay, please provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:

• State issued document with your organization's Federal Tax ID Number
• State issued document with your organization's Resale Tax ID Number
• City or County issued Business License
• State Department of Health Services License
• Any other ID issued by the State that includes the business name & address

* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. Avantor will not lift restrictions for residential shipping addresses.

Specifications

Enzyme type:
Recombinant
Source:
E. coli
Species:
Mouse
Form:
Lyophilized powder
Reconstitution Instructions:
Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Enzyme Name:
Caspase 8
Enzyme Synonyms:
Active Caspase-8, Caspase-8 Enzyme,caspase-8, caspase-8 assay positive control
Purity:
≥95%