About this item
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Manufactured using all Animal-Free reagents.
- Carrier free
- Animal-free
MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Specifications
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:−20 °C
- Endotoxin Content:<0.1 ng/μg of protein (<1 EU/μg).
- Biological Activity:The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml.
- Animal-Free:Y
- Protein/Peptide Name:NT3
- Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
- Formulation:Lyophilized
- Shipping Temperature:RT