Specifications
- Antibody Type:Primary
- Antigen Name:Sin3A-Associated Protein, 155Kda
- Antigen Symbol:SAP155
- Clonality:Polyclonal
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Size:100 µL
- Cross Adsorption:No
- Form:liquid
- Gene ID:23451
- Antigen Synonyms:155 kDa subunit|pre-mRNA splicing factor SF3b|PRPF10|PRP10|SAP155|pre-mRNA-splicing factor SF3b 155 kDa subunit|Hsh155|SF3b155|SAP 155|pre-mRNA processing 10|splicing factor 3B subunit 1|spliceosome-associated protein 155|spliceosome associated protein 155
- Storage Buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage Temperature:Store at –20 °C for 12 months
- Concentration:1 μg/μl
- Shipping Temperature:4°C
- Purification:Purified by Protein A
- Cat. No.:10463-308
- Supplier no.:BS-7417R-FITC
Specifications
About this item
SAP 155 is a 1,304 amino acid member of the SF3B1 family and contains eleven HEAT repeats. Localized to nuclear speckles and also to the cytoplasm during mitosis, SAP 155 is a subunit of the SF3B splicing factor. The SF3B splicing factor is a U2 snRNP-associated protein complex essential for spliceosome assembly. SF3B contains the spliceosomal proteins SAP 49, SAP 130, SAP 145 and SAP 155. Concomitant with splicing catalysis, SAP 155 is phosphorylated at its N-terminal Thr-Pro dipeptide motifs by Dyrk1A and cyclin E/Cdk2. This modification of SAP 155 is vital for a functional spliceosome as it is an essential event in the basic splicing reaction. Due to alternative splicing events, various SAP 155 isoforms are produced.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: SAP155
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat