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- Antibody Type:Primary
- Antigen Name:absent in melanoma 2
- Antigen Symbol:AIM2
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 488
- Flow Cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Size:100 µL
- Environmentally Preferable:
- Cross Adsorption:No
- Form:liquid
- Gene ID:383619
- Antigen Synonyms:Ifi210,interferon-inducible protein AIM2|PYHIN4,CRYBG2,Gm1313
- Storage Buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage Temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping Temperature:4°C
- Immunogen:250-300/354
- Purification:Purified by Protein A
- Cat. No.:10427-884
- Supplier no.:BS-5986R-A488
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.
Recommended Dilutions: Flow Cytometry: 1:20-100; IF(IHC-P): 1:50-200
Type: Primary
Antigen: AIM2
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat