Specifications
- Antibody Type:Primary
- Antigen Name:Angiotensin Converting Enzyme 2
- Antigen Symbol:ACE2
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Epitope:Center
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:59272
- Antigen Synonyms:Angiotensin-converting enzyme homolog|ACEH|Processed angiotensin-converting enzyme 2|Angiotensin-converting enzyme 2|ACE2|ACE-related carboxypeptidase
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-ACE2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the internal region of human ACE2.
- Purification:Anti-ACE2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Anti-ACE2 has no cross response to ACE1.
- Cat. No.:10799-534
- Supplier no.:600-401-X60
Specifications
About this item
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Recommended Dilutions: ELISA: 1:5000-1:20,000; Immunohistochemsitry: 2 µg/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 0.5 - 2 µg/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: ACE2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype:
Reactivity: Human