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Anti-ACE2 Rabbit Polyclonal Antibody
Anti-ACE2 Rabbit Polyclonal Antibody
Catalog # 10799-528
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Anti-ACE2 Rabbit Polyclonal Antibody
Catalog # 10799-528
Supplier Number:  600-401-G71

Specifications

  • Antibody Type:
    Primary
  • Antigen Name:
    Angiotensin Converting Enzyme 2
  • Antigen Symbol:
    ACE2
  • Clonality:
    Polyclonal
  • Conjugation:
    Unconjugated
  • Host:
    Rabbit
  • Reactivity:
    Human
  • Western Blot:
    Yes
  • Size:
    100 µg
  • Epitope:
    C-Terminal
  • Format:
    IgG
  • Form:
    Liquid (sterile filtered)
  • Gene ID:
    59272
  • Antigen Synonyms:
    Angiotensin-converting enzyme homolog|ACEH|Processed angiotensin-converting enzyme 2|Angiotensin-converting enzyme 2|ACE2|ACE-related carboxypeptidase
  • Concentration:
    1 mg/mL by UV absorbance at 280 nm
  • Shipping Temperature:
    Dry Ice
  • Immunogen:
    ACE2 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2.
  • Purification:
    Anti-ACE2 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with ACE2 with Human based on 100% homology with the immunizing sequence. Cross-reactivity with ACE2 from other sources has not been determined. Anti-ACE2 has no cross response to ACE1.
  • Cat. No.:
    10799-528
  • Supplier no.:
    600-401-G71

Specifications

About this item

ACE2 antibody detects human ACE2. Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently, ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. Anit-ACE2 antibodies are ideal for investigators involved in enzyme and cardiovascular research.

Recommended Dilutions: Western Blot: 0.5-2 ug/mL; contains 0.01% (w/v) Sodium Azide

Type: Primary
Antigen: ACE2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype:
Reactivity: Human