Specifications
- Antibody Type:Primary
- Antigen Name:CASP8 And FADD-like apoptosis regulator
- Antigen Symbol:CFLAR
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Epitope:N-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:8837
- Antigen Synonyms:c-FLIP|c-FLIPS|CLARP|FLAME-1|I-FLICE|MRIT|CASP8AP1|FLAME|c-FLIPL|c-FLIPR|FLIP|FLAME1|CASH|Casper
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-FLIP antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the N-terminus of human FLIP. The sequence is identical in all FLIP splice variants.
- Purification:Anti-FLIP Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. FLIP recognizes all FLIP splice variants including FLIPa, b, and y.
- Cat. No.:10802-898
- Supplier no.:600-401-BF3
Specifications
About this item
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPalpha, beta, gamma, and delta, respectively.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 5 ?g/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: CFLAR
Clonality: Polyclonal
Clone: 0
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: