Specifications
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Size:0.01 mg
- Tag sequence:Tag free
- Biological Activity:Measured in a cell proliferation assay using human umbilical vein endothelial cells ( HUVEC ). The ED50 for this effect is typically 3. 5 ng/mL.
- Protein Synonyms:VEGF164|VEGFA|VPF
- Protein/Peptide Name:VEGF164
- Purity:>92% as determined by SDS-PAGE.
- Molecular Weight:19.3 kDa
- Formulation:Lyophilized, PBS, pH7.4
- Tested Applications:Western Blot
- Cat. No.:10797-926
- Supplier no.:96-771
Specifications
About this item
Vascular endothelial growth factor A (VEGFA) is also known as Vascular permeability factor (VPF). VEGFA belongs to the PDGF/VEGF growth factor family. VEGFA is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. VEGFA is produced by a group of three major isoforms as a result of alternative splicing and if any three isoforms are produced (VEGFA120, VEGFA164, and VEGFA188) then this will not result in vessel defects and death of the full VEGFA knockout in mice.