The Thermo Scientific MAbPac™ HIC-Butyl column is a high-resolution polymer-based hydrophobic interaction chromatography (HIC) column designed for the separation of mAbs and antibody-drug conjugates (ADCs). The hydrophilic resin and optimal density of the butyl groups lead to excellent bio-compatibility and low carryover. In addition, MAbPac HIC-Butyl column provides complementary selectivity to MAbPac HIC-10 and MAbPac HIC-20 columns.

• Optimal selectivity for ADCs
• High resolution and high efficiency
• Stable at wide range of pH (2−12)
• Low carryover
• Rugged column packing

The MAbPac HIC-Butyl column is based on hydrophilic, non-porous, 5 μm polymer particles functionalized with butyl groups. The hydrophilic resin provides biocompatibility and low carryover while the optimal density of the butyl groups provides high resolution separation.