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Anti-RFWD3 Rabbit Polyclonal Antibody
  10093-602
Anti-RFWD3 Rabbit Polyclonal Antibody
  10093-602
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  • Antibody Type:
    Primary
  • Antigen Name:
    Ring Finger And WD Repeat Domain 3
  • Antigen Symbol:
    RFWD3
  • Clonality:
    Polyclonal
  • Conjugation:
    Unconjugated
  • ELISA:
    Yes
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western Blot:
    Yes
  • Size:
    150 µL
  • Antigen Synonyms:
    RNF201
  • Storage Buffer:
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Shipping Temperature:
    Store at -20°C
  • Immunogen:
    Fusion Protein
  • Purification:
    Antigen affinity Purification
  • Cat. No.:
    10093-602
  • Supplier no.:
    19893-1-AP

 

 

RFWD3, also named as RNF201, is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. From BLAST result, this antibody is specific to RFWD3. 45kd and 55kd maybe splicesome of RFWD3.

Western Blot: Mouse lung Tissue, 1:500-1:5000; IHC: Human Testis, 1:20-1:200; IF: Hela, 1:20-1:200

Type: Primary
Antigen: RFWD3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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