Specifications
- Protein/Peptide Type:Recombinant
- Source:CHO cells
- Species:Human
- Size:0.005 mg
- Biological Activity:Determined by its ability to inhibit human Myostatin (GDF-8) activity in MCP-11 cells. The ED50 for this effect is 0.0025-0.0040 μg/mL in the presence of 5 ng/mL of human Myostatin (GDF-8).
- Protein Synonyms:GASP-1|GASP1|KIAA0443|G-protein coupled receptor-associated sorting protein 1|GASP
- Protein/Peptide Name:GASP1
- Purity:>95%
- Formulation:Lyophilized
- Cat. No.:10073-076
- Supplier no.:40-591
Specifications
About this item
Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-β binding protein that contains multiple protease inhibitor structural domains. It is expressed primarily in the ovary, testis, and brain, and can act as a potent soluble inhibitor of myostatin and GDF-11, but not Activin-A. The GASP-1 gene encodes a 571 amino acid protein that contains a 29 amino acid secretion signal sequence, and multiple identifiable structural features, including a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, two tandem Kunitz domains, and a netrin domain. Recombinant human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66 kDa by SDS-PAGE analysis under non-reducing conditions.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.