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Specifications
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:0.002 mg
- Biological Activity:Endotoxin level is less than 0.1 ng per μg (1EU/μg).
- Protein Synonyms:C16orf77|Interleukin-34|IL-34
- Protein/Peptide Name:IL34
- Purity:>95%
- Formulation:Lyophilized
- Cat. No.:10073-032
- Supplier no.:40-560
Specifications
About this item
IL-34 is a homodimeric cytokine that is expressed in a range of tissues including spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1 stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.