Mouse Recombinant Granzyme B (from Baculovirus (Insect cells))
Catalog # 10072-640
Supplier: Prosci
CAS Number:
Specifications
- Protein/Peptide Type:Recombinant
- Source:Baculovirus (Insect cells)
- Species:Mouse
- Size:0.002 mg
- Biological Activity:Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity, when using the Ac - IEPD - pNA substrate at 25˚C, is greater than 750 nM/min per μg of enzyme.
- Protein Synonyms:CCP1|Ctla1|Ctla-1|AI553453|CCP-1/C11|CTLA-1|GZB
- Protein/Peptide Name:Granzyme B
- Purity:>98%
- Formulation:Lyophilized
- Cat. No.:10072-640
- Supplier no.:40-125
Specifications
About this item
Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues. Recombinant murine Granzyme B is a glycosylated 227 amino acid protein, comprising the mature active portion of the murine Granzyme B precursor. The apparent molecular weight is 28.9 kDa by mass spectrometry.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.