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Specifications
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.005 mg
- Biological Activity:The ED50 was Biological activity was determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10 - 15 μg/mL in the presence of 2 ng/mL of hFasL.
- Protein Synonyms:FASTM|Apo-1 antigen|APO-1|Tumor necrosis factor receptor superfamily member 6|ALPS1A|TNFRSF6|CD95|APT1|FAS1
- Protein/Peptide Name:Fas Receptor (soluble)
- Purity:>98%
- Formulation:Lyophilized
- Cat. No.:10072-916
- Supplier no.:40-311
Specifications
About this item
Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. The full length Fas (receptor) is a 319 amino acid type I transmembrane protein, which contains a 157 amino acid extracellular domain, a 17 amino acid transmembrane domain, and 145 amino acid cytoplasmic domain. Recombinant human soluble Fas (sFas Receptor) is a 157 amino acid polypeptide (17.6 kDa) corresponding to the TNFR homologous cysteine rich extracellular domain Fas.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.