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- Size:250 units
- Enzyme Name:Endonuclease V
- Cat. No.:101227-648
- Supplier no.:M0305S
Endonuclease V is a repair enzyme found in E
Endonuclease V is a repair enzyme found in E. coli that recognizes deoxyinosine, a deamination product of deoxyadenosine in DNA. Endonuclease V, often called Deoxyinosine 3´ Endonuclease, recognizes DNA containing deoxyinosines (paired or not) on double-stranded DNA, single-stranded DNA with deoxyinosines and, to a lesser degree, DNA containing abasic sites (AP) or urea, base mismatches, insertion/deletion mismatches, hairpin or unpaired loops, flaps and pseudo-Y structures. It is believed that Endonuclease V needs another protein to repair the DNA, as it does not remove the deoxyinsoine or the damaged bases. Endonuclease V cleaves the second and third phosphodiester bonds 3´ to the mismatch of deoxyinosine with a 95% efficiency for the second bond and a 5% efficiency for the third bond, leaving a nick with 3´-hydroxyl and 5´-phosphate.
coli.