MabSelect is a protein A affinity resin designed for capturing mAbs from large sample volumes.

• High-flow agarose matrix allows for high flow velocities at production scale enabling the processing of more than 10000 L of feed in one working day
• Oriented coupling of the ligand and optimized matrix gives high dynamic binding capacity which reduces media volume requirements
• Low non-specific binding resulting in low levels of impurities in the product eluate pool
• BioProcess medium supported for industrial applications and well-established in approved processes

MabSelect has been developed for cost-effective high throughput processing of large amounts of feed. This is the reason why MabSelect has been designed-in to several new and second-generation processes for the production of therapeutic MAbs. The medium is based on a highly cross-linked agarose matrix with a recombinant protein A ligand. This ligand is engineered to favor an oriented coupling resulting in an affinity medium with enhanced binding capacity for IgG. The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool. MabSelect is optimized for high capacity, throughput and to deliver a product pool that is high in purity and yield.

The recombinant Protein A ligand is expressed in E. coli and is free of components of mammalian origin. The specificity of binding to the Fc region of IgG is similar to that of native protein A giving a high purification factor in a single step. In addition, the high capacity and the novel base matrix make MabSelect an excellent choice for purification of MAbs at process scale. MabSelect is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect meets industrial demands with security of supply and comprehensive technical and regulatory support.