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Specifications
- Conjugation:Biotin
- Protein Function:Interleukins
- Protein/Peptide Type:Recombinant
- Source:CHO cells
- Species:Human
- Size:1 Vial
- Storage Conditions:–20 °C
- Endotoxin Content:<0.06EU/µg
- Biological Activity:This mutant IL-15/Fc fusion protein specifically binds to the IL-15R, competitively inhibits IL-15-triggered cell proliferation, promotes transplant tolerance, does not activate the STAT-signaling pathway, and exerts a prolonged circulating half-life caused by the modified Fc domain.
- Gene ID:NP_751914.1
- Protein Synonyms:Interleukin-15
- Protein/Peptide Name:IL-15 Mutant H:Fc Ms B 1Vial
- Purity:98%
- Endotoxin Level:Low
- Formulation:Lyophilized. In PBS and 0.09% sodium azide.
- Shipping Temperature:-20 °C, Blue Ice
- Tested Applications:Immunofluorescent staining, Flow cytometry
- Cat. No.:102513-880
- Supplier no.:CHIHF21115MBI1
Specifications
About this item
Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumor mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumor antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumor-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumor effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumor vaccines. Application: Useful for immunofluorescent staining and flow cytometric analysis to identify and enumerate IL-15Ralpha expressing cells within mixed cell populations.