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- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:CHO cells
- Species:Mouse
- Size:50 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<0.06EU/µg
- Biological Activity:Shows the biological function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
- Gene ID:AAH08626.1
- Protein Synonyms:Intercellular Adhesion Molecule 1|ICAM1
- Protein/Peptide Name:CD54
- Purity:98%
- Endotoxin Level:Low
- Formulation:Lyophilized from 0.2µm-filtered solution in PBS.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102511-346
- Supplier no.:MF120ICAM1C050
Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1beta and LPS. Soluble CD54 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.