Mouse Recombinant SuperKillerTRAIL™ (soluble) (from E. coli)

Supplier: Adipogen

Supplier: Adipogen

About this item

TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2;CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A;TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1;LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC).

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Specifications

Conjugation:
Unconjugated
Protein/Peptide Type:
Recombinant
Source:
E. coli
Species:
Mouse
Storage Conditions:
–80 °C
Endotoxin Content:
<0.01EU/µg
Biological Activity:
Induces apoptosis at concentrations of >10ng/ml as tested on human tumor cells. This effect can be efficiently blocked by recombinant mouse TRAIL receptors. This protein does not require a cross-linker (enhancer) for its potent biological activity.
Gene ID:
P50592
Protein Synonyms:
Apo-2L|TRAIL|CD253|TNFSF10
Protein/Peptide Name:
SuperKillerTRAIL™ (soluble)
Purity:
95%
Molecular Weight:
~24kDa
Sequence:
99-291
Endotoxin Level:
Low
Concentration:
0.5mg/ml
Formulation:
Liquid. In 20mM HEPES, pH 7.4, 300mM NaCl, 0.01% Tween 20, 1% sucrose, 1mM DTT.
Shipping Temperature:
-80 °C, Dry Ice