About this item
TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK–Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.
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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Human
- Storage Conditions:–20 °C
- Endotoxin Content:<0.1EU/µg
- Gene ID:Q9NP84
- Protein Synonyms:FGF-inducible 14|CD266|Tweak-receptor|Tumor Necrosis Factor Receptor Superfamily Member 12A|TNFRSF12A
- Protein/Peptide Name:FN14
- Purity:95%
- Molecular Weight:~35kDa (SDS-PAGE).
- Sequence:28-75
- Endotoxin Level:Low
- Concentration:1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS.
- Shipping Temperature:-20 °C, Blue Ice