Human Recombinant CD40L (from CHO Cells)

Supplier: Adipogen

Supplier: Adipogen

About this item

MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.

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Specifications

Conjugation:
Unconjugated
Protein/Peptide Type:
Recombinant
Source:
CHO cells
Species:
Human
Storage Conditions:
–20 °C
Endotoxin Content:
<0.01EU/µg
Biological Activity:
Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml).
Gene ID:
P29965
Protein Synonyms:
ADIPOQ-CD40L|ACRP30headless:CD154|ACRP30headless:TNFSF5|MultimericCD40L™|ACRP30headless:CD40L
Protein/Peptide Name:
CD40L
Purity:
95%
Molecular Weight:
~35-40kDa (SDS-PAGE)
Sequence:
18-111
Endotoxin Level:
Low
Concentration:
0.1mg/ml after reconstitution.
Formulation:
Lyophilized. Contains PBS
Shipping Temperature:
-20 °C, Blue Ice