Human Recombinant TNF alpha (soluble) (from E. coli)

Supplier: Adipogen

Supplier: Adipogen

About this item

Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (MultimericTNF-alpha (Prod. No. AG-40B-0019). Since the MultimericTNF-alpha mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha can be used.

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Specifications

Conjugation:
Unconjugated
Protein/Peptide Type:
Recombinant
Source:
E. coli
Species:
Human
Storage Conditions:
–20 °C
Endotoxin Content:
<0.01EU/µg
Biological Activity:
Induces cell death at a concentration range of 0.01-10ng/ml (ED50= 0.05ng/ml or 2 x 10E7 Units/mg; WEHI 164 cells).
Gene ID:
P01375
Protein Synonyms:
Cachectin|Tumor Necrosis Factor Ligand Superfamily Member 2
Protein/Peptide Name:
TNF alpha (soluble)
Purity:
95%
Molecular Weight:
~17kDa (SDS-PAGE)
Sequence:
85-223
Endotoxin Level:
Low
Concentration:
10 µg size: 0.1 mg/ml after reconstitution.50 µg size: 1 mg/ml after reconstitution.
Formulation:
Lyophilized. Contains PBS.
Shipping Temperature:
-20 °C, Blue Ice