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- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Size:500 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<1EU/µg
- Biological Activity:Shows adipogenic effects in stimulated differentiating 3T3-L1 cells.
- Gene ID:P43490
- Protein Synonyms:Pre-B Cell Colony Enhancing Factor 1|Nicotinamide Phosphoribosyltransferase|PBEF1
- Protein/Peptide Name:Nampt Visfatin
- Purity:90%
- Molecular Weight:~52kDa (SDS-PAGE)
- Sequence:1-491
- Endotoxin Level:Low
- Formulation:Lyophilized. Salt-free.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102511-434
- Supplier no.:40A0018AAC500
Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.