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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Mouse
- Size:50 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<0.1EU/µg
- Biological Activity:Induces GITR-mediated NF-kappaB activation in HEK 293 cells.
- Gene ID:Q7TS55
- Protein Synonyms:Activation-inducible TNF-related Ligand|AITRL|TNFSF18|Glucocorticoid-induced TNF Receptor Ligand
- Protein/Peptide Name:GITRL (soluble)
- Purity:90%
- Molecular Weight:~22kDa (SDS-PAGE)
- Sequence:45-173
- Endotoxin Level:Low
- Concentration:0.5mg/ml
- Formulation:Liquid. 0.2µm-filtered solution in 10mM glycine, pH 10.0.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102514-742
- Supplier no.:AG40A0008C050
Specifications
About this item
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.