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Specifications
- Antibody Type:Primary
- Antigen Name:Melanoma Differentiation-Associated protein 5
- Antigen Symbol:MDA5
- Clonality:Monoclonal
- ELISA:Yes
- Host:Mouse
- ImmunoPrecipitation:Yes
- Isotype:IgG1
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Form:Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
- Antigen Synonyms:Clinically amyopathic dermatomyositis autoantigen 140 kDa|RLR-2|Helicard|Murabutide down-regulated protein|Melanoma differentiation-associated protein 5|RNA helicase-DEAD box protein 116|MDA-5|CADM-140 autoantigen|RIG-I-like receptor 2|Helicase with 2 CARD domains|Interferon-induced with helicase C domain protein 1
- Concentration:1mg/ml
- Purification:≥95% (SDS-PAGE)
- Cat. No.:89155-170
- Supplier no.:804-863-C100
Specifications
About this item
MDA5 and RIG-I are highly conserved helicases involved in the innate immune response to virus. MDA-5 ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. After binding nonself-ligand, RIG-I and MDA5 interact via their CARD domains with the signaling-adaptor molecule, IPS-1 (also known as MAVS, VISA and Cardif), which leads to the induced expression of IFN-β, IRF3-target genes and NF- κB target genes to drive antiviral and inflammatory responses.
- For ELISA, Flow Cytometry, Immunoprecipitation, Western Blot
Recognizes human MDA5.
Type: Primary
Antigen: MDA5
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human