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Specifications
- Source:
- Species:
- Size:100 µg
- Environmentally Preferable:
- Protein/Peptide Name:Toxin A
- Cat. No.:89152-986
- Supplier no.:630-100-C100
Specifications
About this item
Cytotoxic and enterotoxic
Isolated from Clostridium difficile.
Has potent cytotoxic and enterotoxic properties. Translocates to the cytosol of target cells and glucosylates small GTP-binding proteins such as Rho, Rac, and Cdc42. Induces actin condensation, cell death and opening of the tight junctions. Triggers release of pro-inflammatory cytokines from intestinal epithelial cells probably via activation of MAP kinases.