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- Antibody Type:Primary
- Antigen Name:Ubiquitin
- Antigen Symbol:Ubi-1
- Clonality:Monoclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Flow Cytometry:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- Isotype:IgG1
- Reactivity:Bovine
- Western Blot:Yes
- Storage Buffer:PBS pH7.4 containing 0.1% sodium azide
- Storage Temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles
- Immunogen:Ubiquitin from bovine erythrocytes conjugated to bovine gamma globulin
- Tested Applications:Fluorescence-Activated Cell Sorting
- Purification:Protein G affinity purified
- Cat. No.:89360-786
- Supplier no.:GTX20122
Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has a normal role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C-terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
Type: Primary
Antigen: UBIQUITIN
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Cow (Bovine)