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39118 results for Proteins and Peptides

You searched for: Proteins and Peptides

Proteins and Peptides

Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier proteins. These kits, mixture solutions, and collagen matrices fulfill a myriad of essential laboratory functions for developing relationships between proteins and other cellular components. The stimulating proteins offered have various amino acid arrangements and functions to fulfill any sample manipulation for testing purposes in any field.

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Human Recombinant MIG/CXCL9 (from E. coli)

Human Recombinant MIG/CXCL9 (from E. coli)

Supplier: VWR International

Monokine induced by gamma interferon (MIG or CXCL9) is a T cell chemoattractant during neuroinflammatory events. MIG production is stimulated by interferon gamma (IFNɣ) and signals through the chemokine receptor CXCR3.

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Mouse Recombinant IL-7 (from E. coli)

Mouse Recombinant IL-7 (from E. coli)

Supplier: VWR International

Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes.

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Human Recombinant MCP-4  (from E. coli)

Human Recombinant MCP-4 (from E. coli)

Supplier: VWR International

Monocyte chemotactic protein 4 (MCP-4), also called CCL13, is induced by inflammatory proteins such as interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-α). MCP-4 is a ligand for the G protein coupled chemokine receptors CCR2, CCR3, and CCR5. MCP-4 activates signaling in monocytes, T lymphocytes, eosinophils, and basophils during inflammation and allergic responses.

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Human Recombinant FGF-8 (from E. coli)

Human Recombinant FGF-8 (from E. coli)

Supplier: VWR International

Fibroblast growth factor 8 (FGF-8) is a critical mitogenic factor that is required for normal development of the eye, ear, brain, and limb. FGF-8 functions broadly to promote cell proliferation, differentiation, and migration. Overexpression of FGF-8 increases tumor growth and angiogenesis. Human and mouse FGF-8 proteins show 100% homology.

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Dog Recombinant IL-2 (from E. coli)

Dog Recombinant IL-2 (from E. coli)

Supplier: VWR International

Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

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Human Recombinant GDNF (from E. coli cells)

Human Recombinant GDNF (from E. coli cells)

Supplier: VWR International

Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.

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Mouse Recombinant PDGF-AA (from E. coli)

Mouse Recombinant PDGF-AA (from E. coli)

Supplier: VWR International

Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β, and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells.

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Human Recombinant Hematopoietic Stem Cell Expansion Protein Bundle (from E. coli)

Human Recombinant Hematopoietic Stem Cell Expansion Protein Bundle (from E. coli)

Supplier: VWR International

Cytokines for expansion and cell culture of human hematopoietic stem cells. Hematopoietic stem cells are self renewing pluripotent cells often characterized by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with decreased self renewal properties and pluripotent potential.

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Mouse/Rat Recombinant RANTES/CCL5 (from E. coli)

Mouse/Rat Recombinant RANTES/CCL5 (from E. coli)

Supplier: VWR International

Regulated upon activation, normal T cell expressed and secreted (RANTES), also called CCL5, is a chemokine produced by T cells three to five days after T cell activation. RANTES signals through G protein-coupled receptors CCR5, CCR3, CCR1, and through the human CMV-encoded viral receptor US28. RANTES functions to recruit immune cells to inflammatory sites.

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Human Recombinant IFN-A 2B (from E. coli cells)

Human Recombinant IFN-A 2B (from E. coli cells)

Supplier: VWR International

Interferon-alpha 2b (IFN-α 2b) is a type I interferon made by leukocytes during viral infection. The JAK-STAT pathway mediates the antiviral and anti-cell proliferation activities of IFN-α 2b. IFN-α proteins are widely used as standard treatments during antiviral and antineoplastic therapies. The IFN-α 2b variant differs from IFN-α 2a by one amino acid.

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Human Recombinant GRO-G (from E. coli)

Human Recombinant GRO-G (from E. coli)

Supplier: VWR International

Growth regulated protein gamma (GRO-ɣ), also called CXCL3, acts through the chemokine receptor CXCR2 to promote monocyte migration and adhesion. GRO-ɣ also induces the migration of cerebellar granule neuron precursor cells.

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Guinea pig Recombinant IP-10/CXCL10 (from E. coli)

Guinea pig Recombinant IP-10/CXCL10 (from E. coli)

Supplier: VWR International

Interferon gamma-induced protein 10 (IP-10), or CXCL10, is a chemokine secreted by monocytes, endothelial cells, and fibroblasts in response to interferon gamma (IFN-ɣ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and natural killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.

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Human Recombinant SCF (from E. coli)

Human Recombinant SCF (from E. coli)

Supplier: VWR International

Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.

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Mouse Recombinant IL-3 (from E. coli)

Mouse Recombinant IL-3 (from E. coli)

Supplier: VWR International

Interleukin 3 (IL-3) is a cytokine that is produced by activated T cells and mast cells.  IL-3 induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells.  IL-3 also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases.  

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Human Recombinant TNFR-1 (from E. coli)

Human Recombinant TNFR-1 (from E. coli)

Supplier: VWR International

Tumor necrosis factor receptor type 1 (TNFR-1) is expressed in most tissues and is activated by soluble and membrane-bound tumor necrosis factor alpha (TNF-α). TNFR-1 activates NF-κB and MAPK pathways to induce inflammation, promote apoptotic cell death, inhibit tumorigenesis, and inhibit viral replication.

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Human/Mouse/Rat Recombinant BMP-2 (from E. coli)

Human/Mouse/Rat Recombinant BMP-2 (from E. coli)

Supplier: VWR International

Bone morphogenetic protein 2 (BMP-2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Active BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7.

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Human/Mouse/Rat Recombinant BMP-2 (from E. coli)

Human/Mouse/Rat Recombinant BMP-2 (from E. coli)

Supplier: VWR International

Bone morphogenetic protein 2 (BMP-2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Active BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7.

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Human Recombinant NT-4 (from E. coli)

Human Recombinant NT-4 (from E. coli)

Supplier: VWR International

Neurotrophin-4 (NT-4) is an important member of the nerve growth factor (NGF) family of proteins. Neurotrophins undergo paracrine and autocrine signaling to control neuronal survival, neuronal differentiation, and dendrite outgrowth. NT-4 is expressed ubiquitously and signals through the TrkB receptor tyrosine kinase.

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Human Recombinant IL-17E (from E. coli)

Human Recombinant IL-17E (from E. coli)

Supplier: VWR International

Interleukin 17E (IL-17E), also known as IL-25, is a member of the IL-17 family of cytokines. IL-17E binds to the IL-17RB receptor to stimulate the secretion of the proinflammatory interleukin 8 (IL-8) chemokine and to induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).

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Mouse Recombinant IGF-II (from E. coli)

Mouse Recombinant IGF-II (from E. coli)

Supplier: VWR International

Insulin-like growth factor II (IGF-II) is an important fetal growth hormone made by theca cells during gestation. IGF-II engages the IGF-I receptor (IGF1R) to mediate embryonic growth. IGF-II also binds the sink IGF-II receptor (IGF2R) leading to IGF-II degradation.

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Rat Recombinant M-CSF (from E. coli)

Rat Recombinant M-CSF (from E. coli)

Supplier: VWR International

Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. M-CSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy.

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Human Recombinant FGF-5 (from E. coli)

Human Recombinant FGF-5 (from E. coli)

Supplier: VWR International

Fibroblast growth factor 5 (FGF-5) is a secreted heparin-binding growth factor that binds to FGF receptors 1 and 2 (FGFR1 and FGFR2). FGF-5 is expressed in the mesenchyme, skeletal muscles, central nervous system, and hair follicles to promote cell differentiation and proliferation. FGF-5 functions as a regulatory factor during hair elongation and skeletal muscle development.

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Human Recombinant FGF-BASIC 154 (from E. coli)

Human Recombinant FGF-BASIC 154 (from E. coli)

Supplier: VWR International

Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. FGF-basic is a critical component for embryonic stem cell culture systems and is necessary for maintaining cells in an undifferentiated state.

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Mouse Recombinant IL-11 (from E. coli)

Mouse Recombinant IL-11 (from E. coli)

Supplier: VWR International

Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling.

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Human Recombinant RELM-B (from E. coli)

Human Recombinant RELM-B (from E. coli)

Supplier: VWR International

Resistin-like molecule-beta (RELM-β) is a member of the RELM family of secreted proteins containing conserved C-terminus cysteines. The RELM family consists of Resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-ɣ (FIZZ4). Resistin and RELM-β are the only RELM family members found in humans, whereas all four RELM family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodeling and increased inflammation.

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Human Recombinant IL-8 (from E. coli cells)

Human Recombinant IL-8 (from E. coli cells)

Supplier: VWR International

Interleukin 8 (IL-8 or CXCL8) is a member of the CXC cytokine family and is produced by macrophages, epithelial, smooth muscle, and endothelial cells. IL-8 binds the G protein-coupled serpentine receptors CXCR1 and CXCR2. IL-8 recruits innate immune cells, induces phagocytosis, and stimulates angiogenesis.

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Human, Mouse, Rat Recombinant GDF-11 (from E. coli)

Human, Mouse, Rat Recombinant GDF-11 (from E. coli)

Supplier: VWR International

Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

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Mouse Recombinant EGF (from E. coli)

Mouse Recombinant EGF (from E. coli)

Supplier: VWR International

Epidermal growth factor (EGF) is a growth factor that stimulates the proliferation, differentiation, and survival of epithelial and epidermal cells. EGF contains three intramolecular disulfide bonds and binds in high affinity to the epidermal growth factor receptor (EGFR).

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Human Recombinant CHEMERIN (from E. coli)

Human Recombinant CHEMERIN (from E. coli)

Supplier: VWR International

Chemerin is a chemoattractant adipokine that is expressed in white adipose, liver, skin, and lung tissues. Chemerin is a ligand for the G protein-coupled receptor chemokine-like receptor 1 (ChemR23), which is expressed on dendritic cells, macrophages, and adipocytes. Chemerin functions to recruit macrophages to sites of tissue damage and inflammation.

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Rat Recombinant LEPTIN (from E. coli)

Rat Recombinant LEPTIN (from E. coli)

Supplier: VWR International

Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage.

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