Cycloheximide

Supplier: MP Biomedicals

Applications
Cycloheximide is used in protein synthesis in apoptosis. It is also used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production.
Product Description
Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. It exhibits somewhat lower activity against bacteria and certain fungi. It inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis.
Biochem/physiol Actions
Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Supplier: Thermo Scientific Chemicals

A frequently used lab reagent that inhibits fungal growth by targeting protein synthesis.

Supplier: Abcam

Protein synthesis inhibitor. Antifungal antibiotic. Achieve your results faster with highly validated, pure and trusted compounds.

Supplier: Thermo Scientific Chemicals

Cycloheximide 95%

Supplier: MP Biomedicals

Cycloheximide is a glutarimide antibiotic derived from a microbial source. Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. It exhibits somewhat lower activity against bacteria and certain fungi. Control of various molds and fungi in gelatin-based photographic emulsions, photoengraving glues, and other light-sensitive products is suggested.
Cycloheximide is used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production. It is also used in bacteriological media to isolate or count bacteria in the presence of yeast and molds; Used in protein synthesis in apoptosis; Gene expression; Glycogenolysis, gluconeogenesis and ureogenesis in isolated rat hepatocytes; Studies involving steroidogenesis; Used in plant regulation and as a quality control measure by the food and beverage industry.
Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. Cycloheximide inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis. Cycloheximide is also known to induce FAS/FAS Ligand apoptosis, and triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells in addition to a variety of other cell types. Cycloheximide will also delay or inhibit apoptosis induced by other agents.

Supplier: Thermo Scientific Chemicals

Cycloheximide solution, 100mg/mL in DMSO, 0.2 micron filtered. Liquid.

Supplier: Thermo Scientific Chemicals

Powder

Supplier: Enzo Life Sciences

Protein synthesis inhibitor

Supplier: Aladdin Scientific

Cycloheximide, also known as Actidione, is a glutarimide antibiotic commonly derived from the bacterium Streptomyces griseus. It acts as a potent inhibitor of protein biosynthesis in eukaryotic cells by disrupting the translocation step during translation, effectively blocking translational elongation. Application: In yeast strains, cycloheximide has been used as a protein synthesis inhibitor in the cycloheximide chase experiment. It has been used to inhibit translation in mammalian cells.It has been used to suppress fungal growth.

Supplier: G-Biosciences

Translation inhibitor selectively inhibiting eukaryotic protein synthesis via inhibiting tRNA binding and release from ribosomes1. Widely used as a tool for controlled inhibition of protein expression2. May induce or inhibit apoptosis in various cell types3. Typical active concentrations: 10 to 300 µg/ml. Cell permeable. Caution: Toxic.

Supplier: Chem-Impex International

Cycloheximide, derived from the bacterium Streptomyces griseus, is a potent inhibitor of protein synthesis in eukaryotic cells, making it an invaluable tool in molecular biology and biochemistry research. This compound is widely utilized in studies involving gene expression, cellular signaling, and the effects of various compounds on protein synthesis. Its ability to selectively inhibit the elongation phase of translation allows researchers to dissect the roles of specific proteins in cellular processes, providing insights into mechanisms of action for drugs and potential therapeutic targets.

Supplier: G-Biosciences

Apoptosis is commonly defined as programmed mechanism of cell death and is a highly regulated process that can be initiated by a variety of internal and external stimuli (inducers).

Supplier: R&D Systems

Inhibitor of protein synthesis