You searched for: BX-795

Supplier: Enzo Life Sciences

Inhibitor of PDK1, TBK1, IKK-ε, IRF3

Supplier: Ambeed

BX-795 98%

Supplier: Adipogen

BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC(50) 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-epsilon. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC(50) values ranging from submicromolar amounts (0.368µM to greater than 450µM.